MiRNAs profile as biomarkers of nutritional therapy for the prevention of type 2 diabetes mellitus: From the CORDIOPREV study

Background and aim The incidence of type 2 diabetes mellitus (T2DM) has increased worldwide. One the first actions to reduce risk this disease is implement healthy dietary models; however, no universal strategies have so far been established. In addition, MicroRNAs (miRNAs) are emerging as new biomarkers predict disease. We aimed study whether miRNAs could be used select nutritional therapy prevent T2DM development in patients with cardiovascular Methods All from CORDIOPREV without at baseline according American Diabetes Association (ADA) diagnostic criteria (n = 462) were included present study. Of them, after a median intervention period 60 months two diets (Low fat or Mediterranean diets), 107 developed 355 subjects did not develop plasma levels 24 measured by qRT-PCR. was evaluated Cox regression analysis based on intervention. Finally, pathways analyses carried out identify target genes regulated studied cellular processes which associated development. Results showed that low miR-145 higher developing consumption an LFHCC diet. miR-29a, miR-28-3p miR-126 high miR-150 Med interaction miR-29a modulation FoxO, TNF-?, PI3K-AKT, p53 mTOR signaling, Conclusion Our results suggest circulating clinical practice tool for selecting most suitable diet Clinical trials number NCT00924937.